產(chǎn)品詳情
簡(jiǎn)單介紹：
VCU動(dòng)物顱腦損傷儀可以分為細胞顱腦損傷儀(CIC)，電子顱腦損傷儀(eCCI)及液壓顱腦損傷儀(FPI)，這三種產(chǎn)品己廣泛應用于世界范圍內的顱腦創(chuàng )傷研究中心，是目前顱腦創(chuàng )傷模型制作的金標準。
詳情介紹：
創(chuàng )傷性腦損傷(Traumatic Brain Injury,TBI)是神經(jīng)外科常見(jiàn)的病,是導致創(chuàng )傷患者傷殘及死亡的主要原因。研究腦損傷后的神經(jīng)生化、神經(jīng)病理生理等方面的變化,可為探索行之有效的腦保護提供幫助,將有助于提高顱腦損傷患者的生存率及生存質(zhì)量。
VCU動(dòng)物顱腦損傷儀分為液壓沖擊損傷儀(FPI),細胞損傷控制儀(CIC)和電子腦皮質(zhì)挫傷撞擊儀(eCCI)。這三種產(chǎn)品已經(jīng)廣泛應用于世界范圍內的顱腦創(chuàng )傷研究中心,是目前顱腦創(chuàng )傷模型制作的金標準。同時(shí)FPI損傷儀還可應用到眼科損傷模型,CIC細胞損傷儀可以應用到其它種類(lèi)細胞損傷模型的制作。
液壓顱腦損傷儀(FPI)
液壓沖擊損傷儀(Fluid Percussion Injury)主要針對神經(jīng)創(chuàng )傷機制研究。它成為全球研究神經(jīng)創(chuàng )傷廣泛使用的儀器,可以重復一致地產(chǎn)生液壓沖擊損傷(FPI)。
系統優(yōu)點(diǎn)：
- 可方便的排除氣泡;
- 角度刻度可方便觀(guān)察撞擊角度;
- 集成壓基準力輸出,方便校準。
- 精準輸出沖擊壓力;
- 配備高精度的壓力傳感器
電子顱腦損傷儀(eCCI)
電子大腦皮質(zhì)挫傷撞擊儀 (electric Cortical Contusion lmpactor),主要針對腦皮質(zhì)挫傷模型,是神經(jīng)損傷研究機構受歡迎的損傷模型制作工具。動(dòng)物平臺可以和各種立體定位儀搭配使用。
由VCU大學(xué)設計制作的電子大腦皮質(zhì)挫傷撞擊儀，主要針對腦皮質(zhì)挫傷模型。其組件有：堅固的鋁架、動(dòng)物平臺、撞擊控制器和撞擊頭。動(dòng)物平臺可以和各種立體定位儀搭配使用。由線(xiàn)性馬達驅動(dòng)的撞擊頭，可以由控制器來(lái)控制撞擊參數，實(shí)現不同程度的損傷。撞擊頭含有感應器，可以確定速率、撞擊深度及撞擊停留。
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與傳統Feeney's自由落體硬膜外撞擊方法相比有以下優(yōu)點(diǎn):可精準連續地控制撞擊速度,并獲得實(shí)際撞擊深度和停留時(shí)間等參數,而非重量差異很大的撞擊?？删珳手貜椭谱鞔靷麚p傷模型,減少動(dòng)物死亡,使實(shí)驗過(guò)程更加直觀(guān),可控。
The eCCI is constructed with a sturdy aluminum frame to maximize rigidity, thereby ensuring impact accuracy. The support base, animal platform and impactor head are anodized to prevent oxidation and assure equipment longevity.
Product assembly includes the base and support frame, and adjustable animal positioner with an aluminum animal platform to be used in conjunction with a variety of stereotactic mounts. This model utilizes the enhanced linier motor driven impactor and controller. The enhanced impact head also houses a photo-optic sensor to determine velocity, impact depth and dwell, and is extremely reproducible.
細胞顱腦損傷儀(CIC)
細胞損傷控制儀(CI採取電子式控制，適合morphologic、病理理及培養組織損傷后的機制、形態(tài)學(xué)、病理性。細胞損傷控制儀是針對Flexcell Int’l cor tissue culture system。細胞損傷控制儀平均把壓縮氣體送到每個(gè)culture wells，以造成培養組織牽張性的損傷，損傷的嚴重程度是依據氣體在密閉的culture well進(jìn)出的量，細胞損傷控制儀(CIC)是可以搭配Flex ® 29.45cm2 culturing trays I (針對VCU早期的細胞損傷控制儀)和BioFlex® 57.75cm2 culturing trays。因為根據所採用的細胞種類(lèi)、損傷的程度、培養的狀況，受損后的細胞或許會(huì )因為上述因素死掉或要修護，所以VCU的細胞損傷控制儀(CIC)很適合應用在下列領(lǐng)域:細胞受損、修護，死亡，藥介入的反應。
Depending on the cell type, the degree of injury and the culture conditions, the injured cells may die or repair. Therefore, the system can be employed to study the responses to trauma, including cell injury, repair, death or pharmacologic intervention.
The CIC II has been designed for use with a patented, commercially available tissue culture system from Flexcell International Corp. in Hillsborough, N.C. Tissue cultures are grown in culturing wells with stretchable Silastic® membrane bottoms. The CIC II regulates the flow of compressed gas to rapidly pressurize individual culture wells, causing a radial stretch injury to the culture. Injury severity is determined by controlling the flow of gas in and out of the sealed culture well and the peak pressure is captured to provide an accurate indicator of radial stretch.
The CIC II accepts both the Flex I® 29.45cm2 culturing trays, which were used with the earlier CIC Model 94A, and the BioFlex® 57.75cm2 culturing trays.
